Kieran Culkin’s Brothers Join ‘The Second Best Hospital in the Galaxy’

The casting for Kieran Culkin’s alien brothers may just be out of this world.

Shane Culkin, 48, Macaulay Culkin, 43, Christian Culkin, 37, and Rory Culkin, 34, are set to lend their voices to an episode of Kieran’s upcoming Prime Video animated series The Second Best Hospital in the Galaxy.

In a sneak preview obtained by Entertainment Weekly on Tuesday, February 20, Dr. Plowp (Kieran) is seen trying to build a relationship with colleague Dr. Sleech (Stephanie Hsu). Things get tricky, however, when Dr. Plowp’s siblings (Macaulay, Rory, Christian and Shane) enter the picture and become invested in Dr. Sleech’s emotional state.

“Is this a sex dream or a sex nightmare?” Dr. Sleech wonders aloud as she meets Dr. Plowp’s brothers.

“Why not both?” Dr. Plowp responds. “These are my brothers.”

Related: Macaulay Culkin Through the Years

Macaulay Culkin stole hearts across the world when he starred as the mischievous yet adorable Kevin McCallister in Home Alone. Ever since, he has had quite the Hollywood story. From a young age, the former child star has been surrounded by people in the entertainment industry. His father is Kit Culkin, a Broadway actor, and […]

The project will mark the first acting opportunity for all five brothers together. But more than 30 years ago, Kieran, 41, starred alongside his older brother Macaulay in Home Alone and its subsequent sequel, Home Alone 2: Lost in New York, where he played Kevin McCallister’s cousin Fuller McCallister.

After the role, Kieran went on to star in the Father of the Bride franchise. Most recently, he received critical success for his role as COO Roman Roy on the HBO series Succession.

Long before finding fame with his brothers, Kieran remembered a simple childhood being raised in a New York City apartment by his parents.

“It was just a hallway, and there were no separating doors, except for the bathroom, which didn’t have a lock,” he told Vanity Fair in 2018. “They raised seven kids in that apartment— for years! They just kept bringing babies home to this little space.”

Related: ‘Home Alone’ Cast: Where Are They Now?

Home Alone launched the career of Macaulay Culkin — and three decades later, fans are still quoting the iconic 1990s Christmas film. “Christmas is my time of year,” Culkin exclusively told Us Weekly in November 2019. “I get recognized 10 times more between the months of November and January. I have no idea why.” The […]

While Kieran has since found success as a Hollywood actor, he learned from brother Macaulay that fame isn’t all glitz and glamour. In a March 2023 interview with Esquire, Kieran described the discomfort he felt witnessing his brother struggle with overnight fame after appearing in Home Alone.

“Even at that time, as a kid, I remember thinking, ‘That sucks for him,’” he told the publication. “I had this unhealthy relationship with what I did for a living. I really wanted to do it, but I didn’t want to be successful at it.”

The Culkin brothers aren’t the only familiar faces expected to make an appearance on The Second Best Hospital in the Galaxy. Previously, Prime Video confirmed Tracee Ellis Ross, Bowen Yang and Jay Ellis will have roles in the first season of the animated sci-fi comedy.

Season 1 of The Second Best Hospital Galaxy begins streaming on Prime Video Friday, February 23.